How Transnetyx Helps Labs Advance Replacement, Reduction, and Refinement
The principles of the 3Rs—Replacement, Reduction, and Refinement—have long served as the ethical foundation of responsible animal research. Today, they are also becoming central to funding decisions, regulatory expectations, and institutional accountability. Yet for many research programs, turning these principles into consistent, measurable practices remains a challenge.
Transnetyx helps labs move beyond intention and into execution—providing the tools needed to embed the 3Rs directly into daily operations while maintaining scientific rigor and research momentum.
From Ethical Commitment to Operational Reality
The 3Rs are not abstract ideals. They are practical expectations that require data-driven decision-making, transparency, and control across animal programs. As a strategic partner to individual labs and institutions, Transnetyx supports the adoption of responsible research practices through integrated services that reduce variability, streamline compliance, and improve reproducibility.
Our Automated Genotyping, Genetic Monitoring, and Microbiome Analysis, paired with predictive colony management software (Colony+AMI) and real-time compliance tools (tick@lab), give research teams full visibility into their animal programs—helping them demonstrate ethical stewardship alongside scientific excellence.
Replacement: Enabling Smarter Study Design and Planning
Replacement focuses on avoiding or minimizing animal use whenever possible. While not every study can eliminate animal models entirely, better planning and predictive tools can significantly reduce unnecessary use.
By connecting colony data directly to study design, Transnetyx enables researchers to:
Align breeding decisions with real experimental demand
Avoid producing animals that will never enter a study
Use genetic and microbiome insights to design more targeted, efficient experiments
These capabilities help labs apply the spirit of Replacement by ensuring animals are used only when scientifically necessary.
Reduction: Fewer Animals, Stronger Science
Reduction aims to minimize the number of animals required to achieve reliable, meaningful results. Transnetyx addresses this by reducing experimental variability at its source.
Automated Genotyping and Genetic Monitoring ensure genetic clarity and consistency, reducing the need for repeat experiments
Microbiome Analysis helps control a critical source of biological variability
Colony+AMI predictive analytics optimize breeding to prevent overproduction and surplus
The result is stronger data generated from fewer animals—supporting both ethical responsibility and reproducibility.
Refinement: Improving Welfare Through Better Workflows
Refinement focuses on minimizing pain, distress, and lasting harm while improving animal welfare and staff well-being. Transnetyx solutions refine not only animal care, but also the human experience of managing animal programs.
Our tools help labs:
Reduce technician strain by automating repetitive tasks
Minimize difficult culling decisions through demand-driven breeding
Support consistent monitoring and early intervention through real-time colony insights